Published On: Mon, Feb 8th, 2016

Genetic connection between mental disorders and type 2 diabetes

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There are a genetic connection between a few mental disorders and type 2 diabetes, a new research study by US researchers have discovered.

Researchers from the University of Massachusetts in the US illustrated that a gene called ‘DISC1’ — which is considered to perform a role in mental health disorders, for example, schizophrenia, bipolar disorder and a number of kinds of depression, persuades the work of pancreatic beta cells, which create insulin to continue average blood glucose levels.

The researchers learned the work of DISC1 by evaluated two sets of mice. The initial set was genetically manipulated to disturb the DISC1 gene merely in the mouse’s pancreatic beta cells. The second set of mice was kept normal.

The mice with disturbed DISC1 gene illustrated enhanced beta cell death, a smaller amount of insulin secretion and harmed glucose directive, whereas the organized mice were discovered to be usual, the researchers clarified in the research study cited in The FASEB Journal.

The researchers discovered that DISC1 functions by organized the action of a particular protein — GSK3ß — previously identified to be serious for beta cell work and continued existence. Inhibition of GSK3ß consequence in recovered beta cell continued existence and returned usual glucose tolerance in mice with disrupted DISC1, the researchers of the research study told.

Rita Bortell, a researcher at Massachusetts University, told that “Our hope is that the association we’ve found linking disrupted DISC1 to both diabetes and psychiatric disorders may uncover mechanisms to improve therapies — even preventative ones — to alleviate suffering caused by both illnesses which are extraordinarily costly, very common, often quite debilitating,”

About the Author

Sidra Muntaha

- Sidra Tul Muntaha is a journalist (MA-Mass Communication and M.Phil in Mass Communication) based in Lahore. She is working as an editor at fashion, style and entertainment in the section of the Kooza. She writes fashion and entertainment articles for The Kooza News.

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