Published On: Thu, May 26th, 2016

Loss of Y chromosome cause for Alzheimer’s disease



A research study has stated that men with blood cells that don’t hold the Y chromosome are at elevated danger of being identified with Alzheimer’s disease.

The Y chromosome is included in the two sex chromosomes in humans – the further is the X chromosome. Women don’t hold a Y chromosome.

The missing of the Y chromosome (LOY) is recognized to influence more than 20 percent of men who are aged more than 80 and is the very general inherent mutation needed all through a man’s lifetime.

The researchers of the international research team examined the missing of the Y chromosome in more than 3,200 men with a standard age of 73, and an age varies of 37-96.

As well, the researchers discovered that the people with an accessible analysis of Alzheimer’s disease (AD) had an elevated degree of missing of the Y chromosome and that it was as well a marker for the probability of growing the disease all through the follow-up spell.

Consequently, the results presented in American Journal of Human Genetics could direct to an easy test to recognize those at the peril of growing Alzheimer’s disease.

Lars Forsberg, who is the lead researcher from Uppsala University in Sweden, stated that “The addition of LOY (loss of the Y chromosome) testing in the general population could give medical practitioners the possibility of using preventive strategies in men at risk,”

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Employing standard molecular methods, the recognition of the loss of the Y chromosome in blood is simple to find out when it happens in 10 percent or much of blood cells with a nucleus holding DNA.

In addition to being comparatively frequent in older men, it also happens less often in those who are younger.

Since, women don’t hold a Y chromosome, and men have, on standard, shorter lives, it is likely that missing of the Y chromosome can be pertaining to the earlier death of men.

The researchers observed that Alzheimer’s danger because of loss of the Y chromosome in blood cells is in addition to an elevated peril of death from other reasons, involving a lot of cancers.

Lars Forsberg indicated that “In short, the widespread use of LOY testing could radically decrease male mortality rates, and even perhaps eliminate the difference in life expectancy between the sexes,”


About the Author

Sidra Muntaha

- Sidra Tul Muntaha is a journalist (MA-Mass Communication and M.Phil in Mass Communication) based in Lahore. She is working as an editor at fashion, style and entertainment in the section of the Kooza. She writes fashion and entertainment articles for The Kooza News.