Safe male birth control pills with no side effects583 views
Marking an enzyme possess in testes cells which provide mount to sperm, researchers, involving an Indian-origin reproductive biologist, have found a new mode to grow non-hormonal birth control drug for men that would have no side effects.
The research team discovered a way to create the main enzyme in enough amounts which can direct to future drugs that impede the sperm from floating to the egg.
Jagathpala Shetty, who is a research scientist and co-study author at Virginia University’s school of medicine, stated that “We are on the path toward the male contraceptive drug and this is a noteworthy benchmark along that path,”
The leading researcher of the study, John Herr, further stated that “The milestone reached is the production and isolation of a full-length, active kinase enzyme in sufficient quantities to conduct drug screens,”
By marking this enzyme, its work becomes reserved. It, therefore, reduces the sperm motility, the sperm’s capability to float, consequently fertilization cannot happen.
Herr further stated that “Isolation of an active, full-length form of this enzyme allows us to test drugs that bind to the entire surface of the enzyme so that we can identify inhibitors that may exert a selective action on sperm,”
The research team initially recognized a kinase enzyme that was exclusive only to the testes but, much significantly, was exclusive to the very final stage of sperm production.
These double biological characteristics develop the probability that targeting the enzyme will have influences not any other part in the body.
The author continued as, “Only perfectly healthy men can take the new contraceptive or male ‘pill’. Because of this fact, the drug should be very precise in its mechanism of action, without any off-target side effects on molecules with similar properties located in other organs,”
Herr further added that “The new findings will allow us to have a greater opportunity at identifying the right drug candidates and help guide the program to a drug candidate that binds optimally to the sperm form of this enzyme,”